Best OTC Medicines for Pain
Common over-the-counter options for pain, with typical adult dosing and key safety notes.
Medically reviewed by a licensed pharmacist · Last reviewed
Reviewed against: FDA OTC Monograph · American College of Obstetricians and Gynecologists
Acetaminophen
325-650mg by mouth every 4-6 hours, max 3000mg/day. Take with food if stomach upset occurs. Avoid alcohol while using.
Aspirin
325-650mg by mouth every 4 hours, max 4000mg/day. Take with food to reduce stomach irritation. Stop and consult provider if ringing in ears occurs.
Ibuprofen
200-400mg by mouth every 4-6 hours as needed, max 1200mg/day. Take with food to reduce stomach upset. Stop and consult provider if pain worsens or persists >10 days.
Naproxen
220mg by mouth every 8-12 hours. Max 660mg/day. Take with food to reduce stomach upset.
Topical Camphor
Topical Capsaicin
Apply thin layer to affected area 3-4 times daily. Wash hands thoroughly after application. Burning sensation is normal and typically decreases with continued use over 1-2 weeks.
Topical Diclofenac
Apply thin layer to affected area 3-4 times daily. Rub in gently. Max 32g/day total. Wash hands after application unless treating hands.
Topical Lidocaine
Apply thin layer to affected area up to 3-4 times daily. Max 3 applications per day. Do not use on broken skin or mucous membranes.
Topical Menthol Methylsalicylate
Apply thin layer to affected area 3-4 times daily. Massage gently until absorbed. Wash hands after use unless treating hands. Avoid contact with eyes, mucous membranes, and broken skin.
Trolamine Salicylate Topical
Apply thin layer to affected area 3-4 times daily. Do not use on broken skin or with heating pads.
This page is for general education and is not medical advice. It does not replace a consultation with a licensed pharmacist or your clinician. Always read and follow the product label. If symptoms are severe, worsening, or persistent, seek professional care.