Best OTC Medicines for Skin
Common over-the-counter options for skin, with typical adult dosing and key safety notes.
Medically reviewed by a licensed pharmacist · Last reviewed
Reviewed against: FDA OTC Monograph
Bacitracin Topical
Apply thin layer to affected area. Clean area before application. For external use only.
Benzoyl Peroxide Topical
FDA recommends testing by applying a small amount to 1 to 2 small, affected areas for the first 3 days. Stop use if hives or itching develop, and seek emergency care for throat tightness, difficulty breathing, feeling faint, or swelling of the eyes, face, lips, or tongue
Calamine Topical
Shake well; apply to affected area with cotton 3-4 times daily as needed.
Clotrimazole Topical 1pct
Apply a thin film to the affected area twice daily. Continue for at least 2 weeks (athlete's foot, jock itch) or up to 4 weeks (ringworm) even after symptoms improve.
Colloidal Oatmeal Topical
Apply thin layer to affected area 1-3 times daily as needed. For best results, apply to slightly damp skin and allow to absorb completely.
Diphenhydramine Oral
25-50mg by mouth every 4-6 hours as needed for itch. Max 300mg/day. Causes drowsiness — avoid driving.
Hydrocortisone Topical 1pct
Apply a thin film to the affected area 2-4 times daily. Limit to a maximum of 7 days of continuous use without medical advice.
Miconazole Topical 2pct
Apply thin layer to affected area twice daily for 2-4 weeks. Continue for 1 week after symptoms clear to prevent recurrence.
Pramoxine Topical
Apply to affected area up to 3-4 times daily. For external use only.
Terbinafine Topical 1pct
This page is for general education and is not medical advice. It does not replace a consultation with a licensed pharmacist or your clinician. Always read and follow the product label. If symptoms are severe, worsening, or persistent, seek professional care.