Diphenhydramine Oral Sleep for Sleep
Medically reviewed by a licensed pharmacist · Last reviewed 5/24/2026
Dose
25-50mg by mouth 30 minutes before bedtime. Use for 1-2 nights only. Do NOT take if you'll drive or operate machinery within 8 hours of waking.
What to watch for
- Narrow angle glaucoma
- Severe bph
- Elderly 65 plus
- Maoi use within 14 days
- Concurrent sedatives
Not for children under 18.
Sources
- FDA OTC Monograph
- American College of Obstetricians and Gynecologists
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Where to buy
This page is for general education and is not medical advice. It does not replace a consultation with a licensed pharmacist or your clinician. Always read and follow the product label. If symptoms are severe, worsening, or persistent, seek professional care.