Best OTC Medicines for Sleep
Common over-the-counter options for sleep, with typical adult dosing and key safety notes.
Medically reviewed by a licensed pharmacist · Last reviewed
Reviewed against: FDA OTC Monograph
Chamomile
200-400mg by mouth 30-60 minutes before bedtime. May cause drowsiness; avoid driving after use.
Diphenhydramine Oral Sleep
25-50mg by mouth 30 minutes before bedtime. Use for 1-2 nights only. Do NOT take if you'll drive or operate machinery within 8 hours of waking.
Doxylamine
25mg by mouth 30 minutes before bedtime. Limit to short-term use (1-2 weeks). Do NOT take if driving or operating machinery within 8 hours.
Glycine
500-3000mg by mouth 30-60 minutes before bedtime. Start with 500mg and increase as needed. Generally well-tolerated with minimal side effects.
L Theanine
100-200mg by mouth 30-60 minutes before bedtime. May take with or without food. Start with lower dose to assess tolerance.
Magnesium Glycinate
200-400mg by mouth 30-60 minutes before bedtime. Start with lower dose. May cause loose stools if taken on empty stomach.
Melatonin
Start LOW: 0.3-1mg by mouth 30-60 minutes before target bedtime. Can titrate up to 3mg if needed. Higher doses are not more effective and may worsen morning grogginess. Use for short courses (≤2 weeks).
Passionflower
300-400mg by mouth 30-60 minutes before bedtime. May cause drowsiness; avoid driving or operating machinery after taking.
Tart Cherry
300-480mg by mouth 1-2 hours before bedtime. May take with food to reduce GI upset. Effects may take 1-2 weeks of consistent use.
Valerian Root
300-600mg by mouth 30-60 minutes before bedtime. May cause morning drowsiness; avoid driving until effects are known.
This page is for general education and is not medical advice. It does not replace a consultation with a licensed pharmacist or your clinician. Always read and follow the product label. If symptoms are severe, worsening, or persistent, seek professional care.