Best OTC Medicines for Cough & Cold
Common over-the-counter options for cough & cold, with typical adult dosing and key safety notes.
Medically reviewed by a licensed pharmacist · Last reviewed
Reviewed against: FDA OTC Monograph
Chlorpheniramine
Adults and children ≥12 years: 4mg by mouth every 4-6 hours, max 24mg/day. Children 6-11 years: 2mg every 4-6 hours, max 12mg/day. May cause drowsiness.
Dextromethorphan
10-20mg by mouth every 4 hours, OR 30mg every 6-8 hours. Max 120mg/day.
Dextromethorphan Guaifenesin
Adults and children 12 years and older: Dextromethorphan 15mg and guaifenesin 200mg by mouth every 4 hours. Max 6 doses per day. Take with water to help loosen mucus.
Guaifenesin
200-400mg by mouth every 4 hours, OR extended-release 600-1200mg every 12 hours. Max 2400mg/day. Drink plenty of water.
Honey
1-2 teaspoons by mouth as needed for cough, up to 4 times daily. Not recommended for children under 1 year due to botulism risk.
Menthol Vapor Topical
Apply small amount to chest, throat, or back up to 3-4 times daily. Do not apply to broken skin or under the nose in infants.
Oxymetazoline Nasal
2 sprays in each nostril every 10-12 hours. Do not use for more than 3 days to avoid rebound congestion. Ages 6 and up.
Phenylephrine
10mg by mouth every 4 hours. Max 60mg/day.
Pseudoephedrine
60mg by mouth every 4-6 hours, OR extended-release 120mg every 12 hours. Max 240mg/day. Take last dose by 4pm to avoid insomnia.
Saline Nasal Spray
1-2 sprays in each nostril as needed throughout the day. Safe for frequent use. May cause temporary stinging or sneezing.
This page is for general education and is not medical advice. It does not replace a consultation with a licensed pharmacist or your clinician. Always read and follow the product label. If symptoms are severe, worsening, or persistent, seek professional care.