Best OTC Medicines for Sore Throat
Common over-the-counter options for sore throat, with typical adult dosing and key safety notes.
Medically reviewed by a licensed pharmacist · Last reviewed
Reviewed against: FDA OTC Monograph · American College of Obstetricians and Gynecologists
Acetaminophen
650-1000mg by mouth every 6 hours as needed for pain. Do NOT exceed 4000mg in 24 hours (3000mg if you have liver disease or drink alcohol regularly).
Benzocaine Lozenges
Dissolve 1 lozenge slowly in the mouth every 2 hours as needed. Do not exceed 8 lozenges in 24 hours.
Dyclonine Lozenges
1 lozenge dissolved slowly in mouth every 2 hours as needed. Max 6 lozenges/day. Do not chew or swallow whole.
Hexylresorcinol Lozenges
2.4mg lozenge dissolved slowly in mouth every 2 hours as needed. Max 8 lozenges/day. Do not chew or swallow whole.
Honey
1-2 teaspoons by mouth as needed for sore throat relief. Can be taken straight or mixed in warm water/tea. No established maximum daily limit for adults.
Ibuprofen
200-400mg by mouth every 6 hours with food. Max OTC dose is 1200mg/day. Take with the largest meal of the day if GI sensitive.
Menthol Lozenges
1 lozenge dissolved slowly in mouth every 2 hours as needed. Not for children under 5 years. Max 6 lozenges per day.
Phenol Throat Spray
Spray 1-3 times to affected area every 2 hours as needed. Do not exceed 2 days of use. Avoid swallowing; spit out after use.
Salt Water Gargle
Mix 1/2 teaspoon salt in 8 oz warm water. Gargle for 30 seconds and spit. Repeat 3-4 times daily as needed.
Zinc Lozenges
8.75mg by mouth every 2 hours while awake. Max 6 lozenges/day. Dissolve slowly in mouth, do not chew. May cause nausea or metallic taste.
This page is for general education and is not medical advice. It does not replace a consultation with a licensed pharmacist or your clinician. Always read and follow the product label. If symptoms are severe, worsening, or persistent, seek professional care.